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Nucleic Acids Symposium Series 2001 1(1):111-112; doi:10.1093/nass/1.1.111
© 2001 by Oxford University Press
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Association of vitamin D receptor gene polymorphism with periodontal diseases in Japanese and Chinese

Yoichi Tachi1, Hitomi Shimpuku1, Yasuhiro Nosaka2, Tatsuya Kawamura3, Mitsuko Shinohara1, Masatoshi Ueda4, Hisao Imai4, Kiyoshi Ohura1, Jinglin Sun5, Huanxin Meng5 and Caifang Cao5

1 Department of Pharmacology, Osaka Dental University, 2 Kobe Nishi City Hospital, Peking University School of Stomatology, 3 Kawamura Dental Clinic, Peking University School of Stomatology, 4 Department of Periodontology, Osaka Dental University, 5 Department of Periodontology, Peking University School of Stomatology

We examined whether polymorphisms in the vitamin D receptor (VDR) gene are associated with the incidence of adult periodontitis (AP) and early-onset periodontitis (EOP) in case-controlled studies of Japanese and Chinese subjects. Restriction fragment length polymorphisms in the VDR gene detected by digestion with Taq I were found to be significantly associated with the occurrence of AP or EOP, suggesting that the VDR genotype a risk factor for periodontitis.


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