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Nucleic Acids Symposium Series 2001 1(1):15-16; doi:10.1093/nass/1.1.15
© 2001 by Oxford University Press
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Modulation of DNA-mediated hole transport efficiency by DNA-protein complex formation

Chikara Dohno, Kazuhiko Nakatani and Isao Saito

Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan and CREST, Japan Science and Technology Corporation

To investigate how protein interactions to DNA affects DNA-mediated hole transport, hole transport through the DNA bound to restriction endonuclease BamHI was examined. The DNA bound to BamHI retains a regular B-DNA type of conformation, but have a number of hydrogen bonding interaction. These hydrogen bondings in BamHI-DNA complex suppressed the guanine oxidation and the hole transport in sequence selective manner.


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