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Nucleic Acids Symposium Series 2001 1(1):225-226; doi:10.1093/nass/1.1.225
© 2001 by Oxford University Press
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Molecular design of hairpin imidazole-pyrrole polyamide for effective DNA alkylation

Toshikazu Bando1,2, Akihiko Narita2, Isao Saito1,3 and Hiroshi Sugiyama2

1 CREST, Japan Science and Technology Corporation (JST), Japan, 2 Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan, 3 Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo, Kyoto 606-8501, Japan

A new type of hairpin polyamide-CPI conjugate possessing a vinyl linker has been synthesized. Sequence-selective alkylation of double-stranded DNA by conjugates was investigated by high resolution denaturing gel electrophoresis using 450 bp DNA fragments. Highly-efficient DNA alkylation predominantly occurs at the purines of 5'-(A/T)G(T/A)CPu-3' site at nanomolar concentration.


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