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Nucleic Acids Symposium Series 2001 1(1):23-24; doi:10.1093/nass/1.1.23
© 2001 by Oxford University Press
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New base analogs for the formation of non-natural triplexes

Shigeki Sasaki, Hiroyuki Yamauchi, Ryo Takahasi, Yousuke Taniguchi and Minoru Maeda

Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Novel nucleoside analogs have been designed for selective formation of antiparallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex-forming oligodeoxynucleotide (TFO) incorporating the new analog, WNA-7ßG, formed a stable triplex with high selectivity to the AT site.


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