Nucleic Acids Symposium Series 2001 1(1):31-32; doi:10.1093/nass/1.1.31
© 2001 by Oxford University Press
Stereoselective synthesis of 1'-C-carbon-subsituted 4'-thionucleosides from 4-thiofuranoid glycal
Kazuhiro Haraguchi,
Haruhiko Takahashi and
Hiromichi Tanaka
School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo 142-8555, Japan
PhSeCl or NIS-initiated glycosylation to 25, which were prepared through lithiation of 4-thiofuranoid glycal 1, proceeded stereoselectively to give the target l'-C-carbon-substituted 4'-thiopyrimidine nucleosides. This synthetic method enabled us to synthesize 4'-thioanalogue 13 of nucleoside antibiotic angustmycin.

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