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Nucleic Acids Symposium Series 2001 1(1):49-50; doi:10.1093/nass/1.1.49
© 2001 by Oxford University Press
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Development of chemo-enzymatic process and manufacture of deoxynucleosides

Hironori Komatsu1, Hirokazu Awano1, Hiroki Ishibashi1 and Ichirou Ikeda2

1 Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba 297-0017, Japan, 2 Life Science Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba 297-0017, Japan

Manufacturing method for 2'-deoxynucleosides (dNus) has been developed using novel chemo-enzymatic process. The method consists of the chemical synthesis of 2'-deoxyribose 1-phosphate (dRP) and the enzymatic conversions of dRP into 2'-deoxyadenosine (dA), 2'-deoxyguanosine (dG) and 2'-deoxycytidine (dC). Large-scale preparation is successfully done, which demonstrates an applicability of this strategy to practical use. As thymidine is already under commercial-scale production, all four dNus are now ready for scale-up.


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