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Nucleic Acids Symposium Series 2001 1(1):5-6; doi:10.1093/nass/1.1.5
© 2001 by Oxford University Press
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Synthesis and biological activity of cyclic ADP-carbocyclic-ribose and its analogs as stable mimics of Ca2+-mobilizing second messenger cyclic ADP-ribose

Satoshi Shuto, Takashi Kudoh, Masayoshi Fukuoka, Yoshihito Ueno and Akira Matsuda

Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

Cyclic ADP-carbocyclic-ribose (cADPcR, 2) and its several analogs were designed and synthesized as stable mimics of Ca2+-mobilizing second messenger cyclic ADP-ribose (cADPR, 1). cADPcR was stable and actually caused a significant release of Ca2+ stronger than that of cADPR.


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