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Nucleic Acids Symposium Series 2001 1(1):71-72; doi:10.1093/nass/1.1.71
© 2001 by Oxford University Press
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Chromatin structure of yeast minichromosomes containing triplet repeat sequences associated with human hereditary neurological diseases

Mitsuhiro Shimizu1, Ryo Fujita1, Nobuyuki Tomita1, Heisaburo Shindo2 and Robert D. Wells3

1 Department of Chemistry, Meisei University, Hino, Tokyo 191-8506, Japan, 2 School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan, 3 Institute of Biosciences and Technology, Texas A & M University, Houston, Texas 77030-3303, USA

Expansion of triplet repeat sequences such as (CTG)n, (CGG)n, and (GAA)n causes human genetic diseases. Since DNA is packaged into arrays of nucleosomes in eukaryotic cells, chromatin may be involved in the mechanism of triplet repeat diseases. To elucidate this issue, we have examined effects of triplet repeat sequences on the chromatin organization in vivo using well defined yeast minichromosomes. We show here that (CGG)-12 disrupts an array of positioned nucleosomes, whereas (CTG)12 promotes the nucleosome formation. Thus, triplet repeat sequences can affect the chromatin organization in vivo, which may contribute to the triplet repeat expansion or alterations in the expression of genes associated with triplet repeat diseases.


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