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Nucleic Acids Symposium Series 2001 1(1):75-76; doi:10.1093/nass/1.1.75
© 2001 by Oxford University Press
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Synthesis and biological properties of DNA-peptide conjugates

Takanori Kubo1, Kinuko Yokoyama1, Kotomi Sasaki1, Krishna K. Dubey1 and Masayuki Fujii1,2

1 Department of Environmental and Biological Chemistry, Kyushu School of Engineering, Kinki University, 2 Henkel Research Center of Advanced Technology, Molecular Engineering Institute, Kinki University

Some naturally occurring nuclear localizing signals (NLSs) and some artificially designed peptides were covalently conjugated by solid phase fragment condensation (SPFC) mehtod. These DNA-peptide conjugates showed enhanced permeability into cells as well as enhanced hybrid stability with ss DNA and ds DNA, and also higher resistance against nuclease digestion.


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