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Nucleic Acids Symposium Series 2001 1(1):85-86; doi:10.1093/nass/1.1.85
© 2001 by Oxford University Press
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Trinuclear Cu(II) complex for internucleoside linkage-specific cleavage of RNA

Kazunari Matsumura1, Shinichiro Kina1, Jun Sumaoka1, Suzanne Tobey2, Eric V. Anslyn2 and Makoto Komiyama1

1 Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan, 2 Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA

Trinuclear Cu(II) complex of N,N,N',N',N'',N''-hexa[(2-pyridyl)methyl]-l,3,5-tris(aminomethyl)benzene (L3A) exhibits remarkable substrate-specificity for hydrolysis of 2' -> 5' and 3' -> 5' ribonucleotides. Up(2' -> 5')U is hydrolyzed much efficiently than is Up(3' -> 5')U, but Ap(3' -> 5')A is overwhelmingly preferable to Ap(2' -> 5')A.


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