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Nucleic Acids Symposium Series 2003 3(1):5-6; doi:10.1093/nass/3.1.5
© 2003 by Oxford University Press
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Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase

Yukio Kitade1, Hiroharu Kojima1, Fazila Zulfiqur1, Saori Yabe1, Daisuke Yamagiwa1, Yasutomo Ito1, Masayuki Nakanishi1, Yoshihito Ueno1, Hye-Sook Kim2 and Yusuke Wataya2

1 Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan, 2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan

Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.


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