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Nucleic Acids Symposium Series 2003 3(1):55-56; doi:10.1093/nass/3.1.55
© 2003 by Oxford University Press
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Palladium-catalyzed H-D exchange into nucleic acids in deuterium oxide

Hironao Sajiki, Fumiyo Aoki, Hiroyoshi Esaki, Tomohiro Maegawa and Kosaku Hirota

Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan

We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleic acids. The results presented here provide a deuterium gas-free, totally catalytic and post-synthetic deuterium labeling method in D2O media.


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