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Nucleic Acids Symposium Series 2003 3(1):59-60; doi:10.1093/nass/3.1.59
© 2003 by Oxford University Press
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Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted aarabinofuranosyluracils

Hiroaki Ozaki, Kiyohiro Nakajima, Kyoko Yajima, Kaoru Tatsui, Masayasu Kuwahara and Hiroaki Sawai

Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan

The oligodeoxyribonucleotides (ODN) containing C-2 and/or C-5 substituted arabinofuranosyluracils were synthesized by a post-synthetic modification method. The duplex stability of the ODN bearing isocytosine derivative with DNA was lower than that of the normal ODN/DNA duplex but the ODN bearing C5-substituted uracil derivative was similar to the normal ODN/DNA duplex.


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