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Nucleic Acids Symposium Series 2003 3(1):71-72; doi:10.1093/nass/3.1.71
© 2003 by Oxford University Press
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Photoreactivity of 5-iodouracil-containing telomeric DNA

Yan Xu1 and Hiroshi Sugiyama2

1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo 101-0062, Japan, 2 Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

The photoreaction of 5-iodouracil-(IU)-containing telomeric oligonucleotides in parallel or antiparallel structures, generated in the presence of K+ or Na+ ions, was investigated. It was found that the photoreactivity of telomeric DNA depends on the differences in the quadruplex conformations in the presence of K+ or Na+ ions.


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