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Nucleic Acids Symposium Series 2003 3(1):77-78; doi:10.1093/nass/3.1.77
© 2003 by Oxford University Press
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Helix formation of oligodeoxyribonucleotides containing base-aromatic ring conjugates

Mio Kubota, Momo Kosuge and Akira Ono

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-ohsawa 1-1, Hachioji, Tokyo 192-0397, Japan

Novel nucleoside analogues with base moieties containing pyrene groups have been synthesized and incorporated into oligodeoxyribonucleotides (ODNs). ODNs containing tandem pyrene residues at the 5'-end gave fluorescence spectra characteristic of eximers that were diminished by duplex formation of the ODNs with complementary strands.


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