Nucleic Acids Symposium Series 2003 3(1):9-10; doi:10.1093/nass/3.1.9
© 2003 by Oxford University Press
Synthetic studies and properties of N-tert-butylaminoxyl nucleosides
Mariko Aso,
Toshiyuki Kaneko,
Morihide Nakamura,
Yasuhiro Matsui,
Noboru Koga and
Hiroshi Suemune
Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.

CiteULike
Connotea
Del.icio.us What's this?
Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our
Customer Services Department.