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Nucleic Acids Symposium Series 2000 44(1):13-14; doi:10.1093/nass/44.1.13
© 2000 by Oxford University Press
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DNA binding of a basic leucine-zipper protein with novel folding domain

Shin-ichi Sato, Keisuke Makino and Takashi Morii

Institute of Advanced Energy, Kyoto University, Uji, Kyoto 611-0011, Japan

DNA-binding proteins frequently utilize short {alpha}-helices as their critical DNA recognition elements. In this research, we have employed the structure-based design to construct a small domain that could target the specific DNA sequences recognized by the yeast transcriptional activator GCN4. The new DNA binding motif recognizes specific DNA sequences as a dimer with high affinity and specificity under the physiological conditions.


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