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Nucleic Acids Symposium Series 2000 44(1):23-24; doi:10.1093/nass/44.1.23
© 2000 by Oxford University Press
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Synthesis of 2'-O-Deuteriomethyl ribonucleosides Gm-d3,Am-d3, Um-d3 and Cm-d3

Takeshi Hashizume

Department of Medicinal Chemjstry, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA

The synthesis of 2'-O-deuteriomethyl ribonucleosides by iodomethane-d3 (99.5+ atom % D) deuteriomethylation of 3',5'-O-tetra(isopropyldisiloxane)-diyl nucleosides,followed by deprotection, is described.


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