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Nucleic Acids Symposium Series 2000 44(1):35-36; doi:10.1093/nass/44.1.35
© 2000 by Oxford University Press
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Control of electron transfer in DNA by peptide nucleic acids (PNA)

Kazuhito Tanabe, Kohzo Yoshida, Chikara Dohno, Akimitsu Okamoto and Isao Saito

Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan and CREST, Japan Science and Technology Corporation, Japan

The one-electron oxidation of PNA-DNA hybrid containing G-triplet sequence was examined. In DNA duplex G-triplet was selectively cleaved by oxidation, whereas in PNA-DNA hybrid cleavage efficiency was extremely lowered. These result suggested that cleavage efficiency of PNA-DNA hybrid was different from that of B-form DNA duplex.


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On the stability of peptide nucleic acid duplexes in the presence of organic solvents
Nucleic Acids Res., May 11, 2007; 35(10): 3367 - 3374.
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