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Nucleic Acids Symposium Series 2000 44(1):45-46; doi:10.1093/nass/44.1.45
© 2000 by Oxford University Press
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The synthesis of pyrrole(Py)/imidazole(lm) polyamide CPI conjugates which possess DNA interstrand cross-linking activity

Toshikazu Bando1,2, Hirokazu lida1,2, Isao Saito1,3 and Hiroshi Sugiyama2

1 CREST, Japan Science and Technology Corporation (JST), Japan, 2 Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan, 3 Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

Covalent dimers of ImPyLDu86 with various linkers were synthesized and their DNA interstrand cross-linking abilities were examined. Denaturing polyacrylamide gel electrophoresis indicated that dimer molecule with tetramethylene linker efficiently produced interstrand cross-link only in the presence of appropriate partner PyIm triamides.


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