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Nucleic Acids Symposium Series 2000 44(1):59-60; doi:10.1093/nass/44.1.59
© 2000 by Oxford University Press
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Electrochemical characterization and DNA-binding property of dipyridophenazine complexes of osmium (II)

Kenichi Maruyama1, Yuji Mishima2, Yasuo Nakabayashi3 and Junko Motonaka1

1 Department of Chemical Science and Technology, The University of Tokushima, Minamijosanjima 2-1,Tokushima 770-8506, Japan, 2 Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, 3 Faculty of Engineering and HRC, Kansai University, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan

Novel dipyridophenazine (DPPZ) complexes of osmium (II), [Os(L)2(DPPZ)]2+ {L= 2,2'-bipyridyl(bpy)(l), 4,4'-diamino-2,2'-bipyridyl (DA-bpy)(2), 4,4'-dimethyl-2,2'-bipyridyl(DM-bpy)(3), and 4,4'- dicarboxyl-2,2'-bipyridyl (DC-bpy)(4)} have been synthesized and characterized. The DNA- binding properties of the complexes were studied by electrochemical methods. As the results, complex 2 shows higher affinity to DNA than other osmium complexes. The binding constant, K of complex 2 to calf thymus DNA has been determined to be 2.3 x 107 M–1 by normal pulse voltammetry (NPV).


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