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Nucleic Acids Symposium Series 2000 44(1):63-64; doi:10.1093/nass/44.1.63
© 2000 by Oxford University Press
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Atomic force microscope of drug-DNA interaction

Kazufumi Masuda, Takao Nakata and Keietsu Tamagake

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan

We have been investigated the possibility of B-Z transition in ZnTMPyP-DNA interaction based on the observation of spectroscopic data.1 In this study, we found drastic change in the AFM image of supercoiled plasmid DNA when it was interacted with TMPyPs indicating that the considerable amount of unwinding of double helix or B-Z transition is induced by the drug-DNA interaction. Such phenomena were not observed for other cationic drugs examined.


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