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Nucleic Acids Symposium Series 2000 44(1):67-68; doi:10.1093/nass/44.1.67
© 2000 by Oxford University Press
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Separation of triplet repeat DNA by capillary electrophoresis and the conformational analysis by atomic force microscope

Tatsuo Nakagawa1, Masanori Ueda2 and Yoshinobu Baba1,2

1 Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan, 2 CREST, Japan Science and Technology Corporation, Chiba 292-0812, Japan

We investigated the relationship between electrophoretic behaviors and higher order structures of triplet repeat DNA fragments by means of capillary electrophoresis and atomic force microscopy (AFM). It was suggested that the mobility difference between triplet repeat DNA and random sequence DNA should be correlated to differences in their dynamic conformation.


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