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Nucleic Acids Symposium Series 2004 48(1):121-122; doi:10.1093/nass/48.1.121
© 2004 by Oxford University Press
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Structural stability and length of I-motif of G-quartet in DNA octaplex

Kenta Mitomi, Tanashaya Ciengshin, Jiro Kondo and Akio Takénaka

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8501, Japan

To confirm that longer DNA strands with sequences gcGA[G]nAgc can from an octaplex, X-ray analyses at n>l have been performed. Several crystals of d(gcGA[G]2Agc) are obtained under different conditions. It has been found that the crystal obtained with cobalt hexamine suggests a hexaplex formation, while the crystal obtained with Mg2+ and Na+ ions suggests an octaplex formation.


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