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Nucleic Acids Symposium Series 2004 48(1):173-174; doi:10.1093/nass/48.1.173
© 2004 by Oxford University Press
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Improved performance of a DNA nanomachine by cationic copolymers

Naoki Makita1, Satoru Inoue1, Toshihiro Akaike1 and Atsushi Maruyama2,3

1 Department of Biomolecular Engineering, Graduate School of Biosdence and Biotechnology, Tokyo Institute of Technology, 2 PRESTO, JST, 3 Institute of Materials Chemistry and Engineering, Kyushu University

We have reported previously that the cationic comb-type copolymer, PLL-g-Dex, accelerated DNA strand exchange reaction while stabilizing DNA duplexes1,2. In this research, we studied the effects of PLL-g-Dex on a DNA-fueled nanomachine. The copolymer enabled rapid and secure operations of the DNA nanomachine which utilized the structural transition between intramolecular G-quadruplex and inter molecular double helix3.


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