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Nucleic Acids Symposium Series 2004 48(1):19-20; doi:10.1093/nass/48.1.19
© 2004 by Oxford University Press
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Efficient generation of 2'-deoxyuridin-5-yl at 5'-(G/C)AAXUXU-3' (X = Br, I) sequences in duplex DNA under UV-irradiation

Takayoshi Watanabe1, Toshikazu Bando2, Yan Xu2 and Hiroshi Sugiyama2

1 School of Biomedical Science, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan, 2 Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto 606-8502, Japan

A highly sequence-specific photoreaction of 5'-(G/C)AAXUXU-3' was found by using 450-base pair DNA fragments containing XU under UV-irradiation (X = Br, I). The molecular basis of this high photoreactivity was investigated in detail using synthetic octanucleotides. Based on the experimental data, the mechanism for the efficient photoreaction was proposed.


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