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Nucleic Acids Symposium Series 2004 48(1):205-206; doi:10.1093/nass/48.1.205
© 2004 by Oxford University Press
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Molecular design of alkylating pyrrole-imidazole polyamides with indole linker

Shunta Sasaki1, Akihiko Narita1, Toshikazu Bando2 and Hiroshi Sugiyama2

1 School of Biomedical Science, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan, 2 Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan

A series of novel DNA alkylating polyamide possessing indole linker was synthesized. The reactivities and specificities of these polyamides with double strand DNA were investigated by using high-resolution gel electrophoresis. The results revealed that the indole linker linked Py-Im polyamides have the high alkylating activities and sequence specificities comparable to vinyl linker linked Py-Im polyamides.


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