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Nucleic Acids Symposium Series 2004 48(1):229-230; doi:10.1093/nass/48.1.229
© 2004 by Oxford University Press
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Aminated poly(L-histidine) as new pH-sensitive DNA carrier

Shoichiro Asayama, Ai Hamaya, Takashi Sekine, Hiroyoshi Kawakami and Shohji Nagaoka

Department of Applied Chemistry, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan

The endosomal escape of the polyion complex between DNA and polycation is one of important factors for efficient gene expression. Here we have examined whether the poly(L-histidine) with several aminoethyl groups, i.e., aminated poly(L-histidine), possessed the pH-sensitive properties as DNA carrier. The polyion complex formation of the aminated poly(L-histidine) with DNA was affected by the endosomal pH of the medium, leading to significant transfection activity.


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