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Nucleic Acids Symposium Series 2004 48(1):27-28; doi:10.1093/nass/48.1.27
© 2004 by Oxford University Press
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Synthesis of peptide ribonucleic acid consisting of D- and L-{gamma}-glutamic acid as a backbone structure

Takehiko Wada1,2, Yusuke Hashimoto2, Hirofumi Sato1,2 and Yoshihisa Inoue2,3

1 PRESTO, JST, Yamada-oka, Suita 565-0871, Japan, 2 Department of Molecular Chemistry, Osaka University, Yamada-oka, Suita 565-0871, Japan, 3 ICORP Entropy Control Project, JST, 4-6-3 Kamishinden, Toyonaka 565-0085, Japan

A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of {gamma}-glutamic acid backbone upon structure elucidated by CD spectra.


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