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Nucleic Acids Symposium Series 2004 48(1):33-34; doi:10.1093/nass/48.1.33
© 2004 by Oxford University Press
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Design of sensing ribonucleopeptides for small ligands

Masaki Hagihara, Tetsuya Hasegawa, Yukiko Tanabe, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo and Takashi Morii

Institute of Advanced Energy, Kyoto University, Uji, Kyoto 611-0011, Japan

Here we report a simple method to convert synthetic receptors to fluorescent sensors. An RNA-peptide complex (ribonucleopeptide) with a known three-dimensional structure is used as a framework of the receptor. Artificial ribonucleopeptide sensors were created with a combination of in vitro selection method and successive modification of the peptide with a fluorophore. A ribonucleopeptide complex of the fluorophore labeled peptide showed a remarkable fluorescence emission change upon binding cognate ligands.


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