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Nucleic Acids Symposium Series 2004 48(1):55-56; doi:10.1093/nass/48.1.55
© 2004 by Oxford University Press
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Design, synthesis and analysis of a pyrrolepolyamide-nucleoside hybrid

Yusuke Ohba, Yusuke Terui, Kazuo Kamaike, Tairo Oshima and Etsuko Kawashima

Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

A pyrrolepolyamide-deoxyguanosine hybrid using the 3-aminopropyl linker (GAP) was designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Apy) and a pyrrolepolyamide-deoxyguanoside hybrid using the 3-aminopropionyl linker (GBP). An evaluation of the DNA binding sequence selectivity of GAP was performed by analysis of CD spectra and Tm values using three DNA duplexes. It was shown that GAP possessed greater binding specificity than distamycin A, netropsin, Apy and GBP.


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