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Nucleic Acids Symposium Series 2004 48(1):69-70; doi:10.1093/nass/48.1.69
© 2004 by Oxford University Press
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Effects of 5-substituted pyrimidine nucleoside bases of WNA on stability of triplex DNA

Yosuke Taniguchi1, Ayako Nakamura1, Yusuke Senko1 and Shigeki Sasaki1,2

1 Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, 2 CREST (JST)

Triplex-forming oligonucleotides (TFOs) are potential DNA-targeting molecules, but their recognizable duplexes are limited to homopurine:homopyrimidine sequences by interruption of pyrimidine bases in the purine strand. Despite numerous studies, this problem has not been generally solved. We have recently demonstrated that the new nucleoside analogues, WNA-ßT and WNA-ßC exhibit selective stabilization of the triplexes at a TA and a CG interrupting site, respectively. However, subsequent investigations have shown that there are limitations in recognizable sequences by these analogs. In this study. we performed further systematic investigation on WNA analogs by synthesizing a variety of WNA analogs having 5-substituted cytosine and uracil, and found that WNA-ßFU exhibit high CG-selectivity.


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