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Nucleic Acids Symposium Series 2005 49(1):25-26; doi:10.1093/nass/49.1.25
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© 2005 Oxford University Press

Synthesis and biological activity of 4'',6''-unsaturated cyclic ADP-carbocyclic-ribose

Takashi Kudoh1, Takashi Murayama2, Akira Matsuda1 and Satoshi Shuto1

1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan, 2 Department of Pharmacology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

4'',6''-unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.


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