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Nucleic Acids Symposium Series 2005 49(1):311-312; doi:10.1093/nass/49.1.311
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© 2005 Oxford University Press

Hydrogen bond removal of pterin derivative whose structure is similar to nucleic acid bases

Mitsuru Nonogawa1, Toshiyuki Arai2, Nobuyuki Endo3, Seung Pil Pack4,5, Tsutomu Kodaki1,5 and Keisuke Makino4,5

1 Institute of Advanced Energy, Kyoto University, Uji 611-0011, Japan, 2 Department of Anesthesia, Kyoto University Hospital, Kyoto 606-8507, Japan, 3 Wakasa Wan Energy Research Center, Tsuruga 914-0129, Japan, 4 International Innovation Center, Kyoto University, Kyoto 606-8501, Japan, 5 CREST (JST)

Pterin, an analog of guanine, is an electron transfer compound in biological systems. Among the analogs, 6-formylpterin (6FP) has been demonstrated to have many marked physiological and pharmacological activities and it is, therefore, worthwhile to elucidate whole mechanism of its activities. Unfortunately, however, 6FP is hardly soluble in water and organic solvents. Like nucleic acid bases, 6FP makes intermolecular hydrogen bonds and forms stacking structure causing such drawback nature. This has made mechanistic studies on 6FP activities extremely difficult. In this study, we carried out derivatization for 6FP and succeeded in increasing water solubility with maintaining its physiological activities.


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