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Nucleic Acids Symposium Series 2005 49(1):43-44; doi:10.1093/nass/49.1.43
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© 2005 Oxford University Press

DNA nanowire sensitive to the surrounding condition

Daisuke Miyoshi1, Zhong-Ming Wang1, Hisae Karimata2 and Naoki Sugimoto1,2

1 Frontier Institute for Biomolecular Engineering Research, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan, 2 Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan

We designed and synthesized an artificial DNA that undergoes a structural transition induced by metal ions. A 2, 2'-bipyridine unit was incorporated into the main chain of d(G4T4G4) instead of thymine. Structural analyses of the artificial DNA with and without metal ions demonstrated that micromolar concentrations of metal ions can induce a structural transition of antiparallel G-quadruplex to a G-wire, which shows the DNA is promising as a controllable and switchable supramolecular device.


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