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Nucleic Acids Symposium Series 2005 49(1):5-6; doi:10.1093/nass/49.1.5
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© 2005 Oxford University Press

Synthesis and properties of 2',4'-BNANC, a second generation BNA

S. M. Abdur Rahman1, Sayori Seki1, Kazushige Utsuki1, Satoshi Obika1,2, Kazuyuki Miyashita1 and Takeshi Imanishi1

1 Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, 2 PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan

We have recently designed and synthesized a novel bridged nucleic acid analogue 2',4'-BNANC, bearing an N-O bridged structure, which furnished both higher duplex and triplex-forming abilities and sequence selectivity towards complementary RNA and/or DNA, respectively, and showed excellent resistance against nuclease degradation. Duplex and triplex-forming abilities were slightly higher or similar to those of 2',4'-BNA and nuclease resistance was as high as that of S-oligo.


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