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Nucleic Acids Symposium Series 2005 49(1):7-8; doi:10.1093/nass/49.1.7
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© 2005 Oxford University Press

Synthesis and alternate-stranded triple helix forming ability of novel anthraquinone modified alpha-beta chimeric DNA

Tomohisa Moriguchi, ATM Zafrul Azam and Kazuo Shinozuka

Department of Chemistry, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan

A series of novel {alpha}-ß chimeric oligonucleotides bearing an anthraquinone-conjugated non-nucleosidic backbone were synthesized as a triplex-forming oligonucleotide (TFO). UV-melting experiments revealed that the obtained modified chimera TFOs form remarkably stable alternate-stranded triplex almost regardless to the stereochemistry of the incorporated non-nucleosidic backbone unit.


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