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Nucleic Acids Symposium Series 2006 50(1):119-120; doi:10.1093/nass/nrl059
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© 2006 Oxford University Press

Synthesis of 5''-substituted cyclic ADP-carbocyclic-ribose as biological tools

Natsumi Sakaguchi1, Takashi Kudoh1, Takashi Murayama2, Mitsuhiro Arisawa1, Akira Matsuda1 and Satoshi Shuto1

1 Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan, 2 Department of Pharmacology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

5''-Branched cyclic ADP-carbocyclic-riboses (4 and 5) were designed as biological tools for identifying the target proteins of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger. One of the targets, 4, successfully synthesized.


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