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Nucleic Acids Symposium Series 2006 50(1):27-28; doi:10.1093/nass/nrl014
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© 2006 Oxford University Press

Structural effect of cationic copolymers on nucleic acid-chaperoning activity

Kaoru Takada1, Sung Won Choi1, Asako Yamayoshi1, Arihiro Kano1 and Atsushi Maruyama1,2

1 Institute for Materials Chemistry and Engineering, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan, 2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

In order to evaluate the effect of cationic copolymer structures on their nucleic acid-chaperoning activity, we prepared various copolymers having different cationic residues or backbone molecular weight. It was revealed that nucleic acid-chaperoning activity increases with increasing molecular weight of the copolymer backbone and that the copolymer having the guanidino groups is effective for increasing nucleic acid-chaperoning activity. Compared with PLL-g-Dex, GPLL-g-Dex has weak activity to stabilize ds DNA. This weak stabilization effect of GPLL-g-Dex may contribute to the higher accelerating effect.


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