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Nucleic Acids Symposium Series 2006 50(1):5-6; doi:10.1093/nass/nrl003
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© 2006 Oxford University Press

Convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP)

Hongbin Yan and Eric Humes

Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, Ontario L2S 3A1, Canada

We herein report a convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP) through the modified H-phosphonate chemistry. The 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) group was used as protecting group for the 2'-hydroxy functions of ribonucleosides. Homogeneous cdiGMP was obtained after removal of the protecting groups.


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