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Nucleic Acids Symposium Series 2007 51(1):11-12; doi:10.1093/nass/nrm006
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© 2007 Oxford University Press

Construction of novel dye aggregates based on "comb-type" sequence

Hiromu Kashida1, Taiga Fujii1 and Hiroyuki Asanuma1,2,*

1Graduate School of Engineering, Nagoya University, Furocho, Chikusa, Nagoya 464-8603, Japan and
2Core Research for Evolution Science and Technology (CREST), Japan Science and Technology Corporation (JST), Kawaguchi, Saitama 332-0012, Japan

* asanuma{at}mol.nagoya-u.ac.jp

Abstract

Novel dye aggregates ("comb-type" aggregates) was prepared by hybridizing modified oligodeoxyribo-nucleotides (ODNs), in which dyes were introduced consecutively. From NMR structural analysis, dye molecules were intercalated between base pairs and stacked in anti-parallel manner. When ODNs containing three Methyl Red moieties were hybridized, strong exciton coupling was observed. In addition, thermal stability of duplex was substantially enhanced due to the intermolecular stacking.


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