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Nucleic Acids Symposium Series 2007 51(1):19-20; doi:10.1093/nass/nrm010
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© 2007 Oxford University Press

A new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability.

Stefano Sforza1, Tullia Tedeschi1, Roberto Corradini1 and Rosangela Marchelli1

1Department of Organic and Industrial Chemistry, Viale G.P. Usberti 17a, University Campus, University of Parma, I-43100 – Parma, Italy

Abstract

By using suitably designed chiral, lysine-based PNAs (chPNAs), the stability of complementary chPNAchPNA duplexes can be depressed, maintaining or improving at the same time the stability of the corresponding PNA-DNA duplexes. This approach could be used in order to develop chPNAs able to perform double duplex DNA invasion.


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