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Nucleic Acids Symposium Series 2007 51(1):193-194; doi:10.1093/nass/nrm097
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© 2007 Oxford University Press

Interaction with and cleavage of DNA by novel phenanthroline polyamine derivative

Takeshi Sasagase, Takeshi Arai, Masayasu Kuwahara, Hiroaki Ozaki and Hiroaki Sawai

Department of Chemistry and Chemical Biology, Graduate School of Engneering, Gunma University, 1-5-1 Tenjin-chou, Kiryu, Gunma 376-8515, Japan

Abstract

Phenanthroline-polyamine conjugates were synthesized by cross-linking of 1,10-phenanthroline to branched polyamines. The conjugates interacted with DNA strongly, and cleaved plasmid DNA hydrolytically without any metal ions under physiological conditions. The phenanthroline-polyamine conjugates also cleaved linear 30mer DNA at the bulged-out region without metal ions under physiologic conditions.


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