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Nucleic Acids Symposium Series 2007 51(1):261-262; doi:10.1093/nass/nrm131
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© 2007 Oxford University Press

Design of peptide nucleic acid by introduction of carbohydrate on lysine linker.

Akira Noguchi1 and Hiroyuki Asan1,2,*

1Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furocho, Chikusaku, Nagoya 4648603, Japan and
2Core Research for Evolution Science and Technology(CREST), Japan Science and Technology Corporation(JST), Kawaguchi, Saitama 3320012, Japan

*Corresponding Author. asanuma{at}mol.nagoyau.ac.jp

Abstract

We synthesized "cartridge" type monomer involving mannose unit on lysine as a linker and additionally inserted it to peptide nucleic acid (PNA) oligomer. Advantage of this procedure is that functional molecule could be easily introduced into anywhere position of PNA without sacrificing basepairs, although such insertion lowered stability of the duplex with DNA.


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