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Nucleic Acids Symposium Series 2007 51(1):365-366; doi:10.1093/nass/nrm183
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© 2007 Oxford University Press

Intermolecular transfer of aminoacylated adenosine towards chemical aminoacylation of tRNA

Mingzhe Liu, Hiroshi Jinmei, Koji Fukuzono, Hiroshi Abe and Yoshihiro Ito*

Nano Medical Engineering Laboratory, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, JAPAN

*Yoshihiro Ito. y-ito{at}riken.jp

Abstract

We synthesized two oligonucleotides: one is DNA conjugated with adenosine derivative at 5' terminus as a donor, another RNA phosphorothioated at 3' terminus as an acceptor. By hybridization of the two oligonuleotides, the adenosine derivative was transferred from the donor DNA to the acceptor RNA. In this study, O, O'-isopropylidene-protected adenosine derivative and aminoacylated adenosine were successfully transferred from the donor to acceptor RNA. By use of tRNA instead of the acceptor RNA, the chemical aminoacylation of tRNA by unnatural amino acid is expected.


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