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Nucleic Acids Symposium Series 2007 51(1):59-60; doi:10.1093/nass/nrm030
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© 2007 Oxford University Press

Chemical biology that controls DNA structure and function

Hiroshi Sugiyama*

Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto 606-8502, Japan

*Corresponding author. E-mail: hs{at}kuchem.kyoto-u.ac.jp

Abstract

All genetic information, which is necessary for life, is written in 3 billion base pairs of DNA. Sequencedependent local DNA conformations are also thought to play an important role in gene expression. Many diseases, including cancer, and hereditary and viral diseases, can now be understood at the DNA sequence and structure level. Therefore, direct control of the expression level of a specific gene would provide a promising approach for knowledge-based therapy. In this presentation I focus on our long-term efforts in controlling of structure and function of DNA by chemical biological approach.


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