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Nucleic Acids Symposium Series 2007 51(1):67-68; doi:10.1093/nass/nrm034
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© 2007 Oxford University Press

Multivalent Catalysts for the Cleavage of Nucleic Acids and their Models

Flavio Manea1, Lucia Pasquato2, Leonard J. Prins1 and Paolo Scrimin1,*

1University of Padova, Department of Chemical Sciences, 35131-Padova, Italy and
2University of Trieste, Department of Chemical Sciences, 34127-Trieste, Italy

*Corresponding Author. E-mail: paolo.scrimin{at}unipd.it

Abstract

Multivalent systems, i.e. systems presenting a discrete collection of several functional groups, are well recognized for their ability to increase binding constants. Less explored is their use as catalysts. We present a number of multivalent nanostructures based on self-assembled gold nanoparticles and dendrimers, which are particularly efficient in the cleavage of nucleic acids and their models.


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