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Nucleic Acids Symposium Series 2007 51(1):73-74; doi:10.1093/nass/nrm037
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© 2007 Oxford University Press

Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization

Longliang Wu1, Naohiko Shimada1, Arihiro Kano1 and Atsushi Maruyama1,2,*

1Institute for Materials Chemistry and Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan and
2CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

*Corresponding Author. maruyama{at}ms.ifoc.kyushu-u.ac.jp

Abstract

We have focused on design of biomaterials that are capable of engineering nucleic acids folding. In this study, we explored the effect of poly(L-lysine)-g-dextran, PLL-g-Dex, copolymer on hybridization kinetics of DNA. The hybridization kinetics was studied by using a fluorescence resonance energy transfer (FRET) assay in the absence and presence of the copolymer. The copolymer at nano molar concentration significantly accelerated the hybridization rate over 200-fold under physiologically relevant ionic conditions.


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