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Nucleic Acids Symposium Series 2007 51(1):75-76; doi:10.1093/nass/nrm038
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© 2007 Oxford University Press

Structural and physicochemical features on the metal-mediated base pairs

Yoshiyuki Tanaka1,*, Shuji Oda1, Hiroshi Yamaguchi1, Kaichiro Haruta1, Takuya Kawamura1, Yoshinori Kondo1, Tomomi Uchiyama1, Miura Takashi1, Hideo Takeuchi1, Hidetaka Torigoe2, Chojiro Kojima3 and Akira Ono4

1Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan 2Graduate School of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, 3Graduate School of Biosciences, NAIST, Ikoma 630-0101, Japan and 4Faculty of Engineering, Kanagawa University, Yokohama 221-8686, Japan

*Corresponding author. E-mail: tanaka{at}mail.pharm.tohoku.ac.jp

Abstract

The chemical structure of the mercury-mediated T-T pair (T-HgII-T) was determined with 15N NMR spectroscopy. In order to determine the chemical structure of the T-HgII-T pair, 15N-15N J-coupling across a metal center (2JNN) was employed. Notably, this is the first observation of 2JNN in a biological macromolecule (DNA duplex). This pairing mode was found to be a irregular metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs.


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