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Nucleic Acids Symposium Series 2008 52(1):143-144; doi:10.1093/nass/nrn073
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Introduction of linkers into PNA for versatile applications

Yuichiro Aiba1 and Makoto Komiyama1

1Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan

*Corresponding Author. E-mail: komiyama{at}mkomi.rcast.u-tokyo.ac.jp.

Abstract

PNA (peptide nucleic acid) is widely used as a DNA recognition tool. In this study, we introduced linkers in the middle of PNAs to expand their applicability. By means of Tm measurement and gel-shift assay, it was confirmed that these PNA can recognize double stranded DNA through efficient invasion.


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